## Abstract The asymmetric synthesis of α‐substituted α‐amino acids and propargylamines is described. As chiral auxiliary we used (__S__)‐(–)‐1‐dimethoxymethyl‐2‐methoxymethylpyrrolidine (SDMP, **1**). Treatment of the amino acids or amines with SDMP **1** afforded the corresponding amidines **C**,
Addition of Amines to the Triple Bond in α,α,α-Trichloromethylpropargyl Mesylate: Synthesis of α,α-Dichloromethylenaminones and Preparation of 2-Phenyl-4-dichloromethylquinolines.
✍ Scribed by Yu-Gui Si; Song-Po Guo; Wan-Jun Wang; Biao Jiang
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 24 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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The addition of the potassium salt of (R)-or (S)-4-phenyl-products were converted into α-amino acids and monosubstituted 1,2-diamines of high enantiomeric purity. 2-oxazolidinone to monosubstituted nitroalkenes proceeded with very good diastereoselectivity. Several of the addition derivatives are in
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