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Addition of Alkyl Vinyl Ethers to Δ 16 -20-Keto Steroids. III

✍ Scribed by Pike, J. E.


Book ID
127240312
Publisher
American Chemical Society
Year
1964
Tongue
English
Weight
838 KB
Volume
29
Category
Article
ISSN
0022-3263

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We have discovered that chlorine in 3~-acetoxy-17-chloro-16-formylandrosta-5,16-diene (1) can be smoothly displaced by nitrogen heterocyclic nucleophiles (her) to give heretofore unknown 17-substituted-A t6 steroids in high yields (73-92%). This enabled us to synthesize novel 3~-hydroxy-17-(1H-1,2,4