Addition of aldehydes and their equivalents to electron-deficient alkenes using N-hydroxyphthalimide (NHPI) as a polarity-reversal catalyst

✍ Scribed by Shinya Tsujimoto; Satoshi Sakaguchi; Yasutaka Ishii

• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 230 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01375-3

✦ Synopsis

Radical addition of aldehydes and masked aldehydes like 1,3-dioxolanes to electron-deficient alkenes was achieved by the use of catalytic amounts of BPO and N-hydroxyphthalimide (NHPI) as a polarity-reversal catalyst under mild conditions. Three-component radical coupling of 1,3-dioxolanes, maleates, and alkenes was performed in the presence of BPO and NHPI under similar conditions.