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Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates its activity

โœ Scribed by Marija Ger; Zigmantas Zitkus; Mindaugas Valius


Book ID
113528550
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
718 KB
Volume
23
Category
Article
ISSN
0898-6568

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## Abstract p120 Ras GTPaseโ€activating protein (RasGAP) encoded by the __rasa1__ gene in mice is a prototypical member of the RasGAP family of proteins involved in negativeโ€regulation of the p21 Ras protoโ€oncogene. RasGAP has been implicated in signal transduction through a number of cell surface r

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## Abstract Mammalian MAP/ERK kinase kinase 1 (MEKK1) was identified as a mammalian homolog of Ste11p of the yeast pheromoneโ€induced mating pathway. Like Ste11p, MEKK1 is a MAP3 kinase linked to at least two MAP kinase cascades and regulatory events that require cytoskeletal reorganization. MEKK1 i