Adaptive optimal designs for dose-finding studies based on sigmoid Emax models

Adaptive Dc-optimal designs for dose fin

Adaptive Dc-optimal designs for dose finding based on a continuous efficacy endpoint

✍ S. Krishna Padmanabhan; Vladimir Dragalin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 355 KB

## Abstract We introduce a new optimal design for dose finding with a continuous efficacy endpoint. This design is studied in the context of a flexible model for the mean of the dose–response. The design incorporates aspects of both __D__‐ and __c__‐optimality and can be used when the study goals u