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Adaptive Design and Estimation in Randomized Clinical Trials with Correlated Observations

✍ Scribed by Guosheng Yin; Yu Shen

Book ID
109223298
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
176 KB
Volume
61
Category
Article
ISSN
0006-341X

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The interim analyses based on group sequential procedures are not convenient if the response time relative to the patient accrual rate is long. Since in most trials patients are accrued and randomized continuously, the response data from those already randomized will continue to accumulate when a tr

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In clinical research, randomized trials are widely accepted as the definitive method of evaluating the efficacy of therapies. Random assignment of patients to treatment ensures internal validity of the comparison of new treatments with controls. An assessment of external validity can best be achieve