Adaptive changes of β-adrenergic receptors after neonatal locus coeruleus lesion: Regulation of serotoninergic unit activity
✍ Scribed by Dr. Laurence Lanfumey; Joëlle Adrien
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 756 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0887-4476
No coin nor oath required. For personal study only.
✦ Synopsis
Spontaneous activity of 5-hydroxytryptamine (5-HT) neurons in the dorsal raphe nucleus (DRN) was recorded in adult rats that had undergone a bilateral locus coeruleus (LC) lesion during the neonatal period. The susceptibility of this neuronal firing to 6-adrenergic manipulation was tested. Microiontophoretic application of the 0-blockers d,l-propranolol and acebutolol inhibited the firing of DRN cells in lesioned rats but not in control animals. This effect was specific to P-receptors since the effects of pharmacological manipulation of other receptors-5-HT, y-aminobutyric acid (GABA), a-adrenoceptorswere identical in lesioned and control animals. The present data demonstrate that a neonatal noradrenergic lesion allowed the persistence of a @-regulation of DRN neuronal firing, which in young rats is normally only transient.