✦ LIBER ✦

Adaptations in 5-HT receptor expression and function: Implications for treatment of cognitive impairment in aging

✍ Scribed by Ellen S. Mitchell; Ross A. McDevitt; John F. Neumaier

Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 252 KB
Volume: 87
Category: Article
ISSN: 0360-4012
DOI: 10.1002/jnr.22100

No coin nor oath required. For personal study only.

✦ Synopsis

Malfunction of the serotonin system may contribute to memory deficits during aging. We evaluated the 5-HT 6 antagonist RO4368554 in two models of learning and memory in aged rats. Male rats (18 months) were assigned to two groups of equal cognitive performance. After 2 weeks of 5-HT 6 antagonist RO4368554 (5 mg/kg, i.p.) treatment, rats showed significant improvement in object recognition and social discrimination compared with rats given chronic vehicle. Brains from these animals were examined for changes in plasticity-associated proteins Ki-67 and PCNA. No differences were seen between groups in any of these markers. We also measured mRNA expression of 5-HT 6 , along with 5-HT 1A , 5-HT 1B , and tryptophan hydroxylase-2 mRNAs in 4-month-old and 24month-old F344 rats. Decreases in 5-HT 1B expression were observed in several forebrain regions in the old rats. These results demonstrate that 5-HT 6 and 5-HT 1B receptors are potential targets for treatment of age-related memory disorders.

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