Adaptation of thymidine utilization to changing rates of DNA synthesis in the cell cycle
β Scribed by Gerald G. Miller; Jean-Claude Schaer; Johannes R. Gautschi; Richard Schindler
- Publisher
- Springer
- Year
- 1979
- Tongue
- English
- Weight
- 675 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0300-8177
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## Background: Although the rate of rna synthesis is known to drop at mitosis, the recent identification of 11 stages in the cell cycle (el-alfy et al., 1994) makes it possible to measure the rate of this synthesis at each one of the stages and thus find out how it varies throughout the cell cycle.
Variations in the rates of DNA and RNA synthesis during the DNA synthetic ( S ) period of the cell cycle have been determined in explants of early Rana pipiens embryos. Cells of dorsal axial ectoderm-mesoderm regions and belly endoderm regions of the embryo were partially synchronized using 5-fluor