Adapalene 0.1% gel and 0.1% cream stimulate RAR mediated gene transcription without significant skin irritation in humans

Adapalene 0·1% gel and adapalene 0·1% cr

Adapalene 0·1% gel and adapalene 0·1% cream stimulate retinoic acid receptor mediated gene transcription without significant irritative effects in the skin of healthy human volunteers

✍ Griffiths; Ancian; Humphries; Poncet; Rizova; Michel; Clucas 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 302 KB

A randomized, investigator masked, intra individual comparative study was conducted in 30 healthy volunteers to compare the cutaneous effects of adapalene 0.1% gel and adapalene 0.1% cream with their respective vehicles, using tretinoin 0.05% cream (n = 21) or tretinoin 0.1% cream (n = 9) and a tret