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ADAM28 is activated by MMP-7 (matrilysin-1) and cleaves insulin-like growth factor binding protein-3

✍ Scribed by Satsuki Mochizuki; Masayuki Shimoda; Takayuki Shiomi; Yutaka Fujii; Yasunori Okada


Book ID
116287903
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
143 KB
Volume
315
Category
Article
ISSN
0006-291X

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Insulin-like growth factor-I (IGF-I) is essential for normal epidermal homeostasis; however, the role of IGF binding proteins (IGFBPs), regulators of IGF action, remains unclear. Here we examine the regulation of human keratinocyte-produced IGFBPs by epidermal growth factor (EGF), transforming growt