ADAM23 Plays Multiple Roles in Neuronal Differentiation of P19 Embryonal Carcinoma cells
โ Scribed by Yaping Sun; Yingming Wang; Jing Zhang; Jing Tao; Chen Wang; Naihe Jing; Chaoqun Wu; Kejing Deng; Shouyi Qiao
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 322 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0364-3190
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The P19 embryonal carcinoma cell line represents a pluripotential stem cell that can differentiate along the neural or muscle cell lineage when exposed to different environments. Exposure to retinoic acid induces P19 cells to differentiate into neurons and astrocytes that express similar development
## Background Pluripotent cells maintain a unique gene expression pattern and specific chromatin signature. In this study, we explored the effect of the methyltransferase inhibitor adenosine dialdehyde (AdOx) on pluripotency maintenance and gene expression in P19 embryonal carcinoma cells. ## Resu
## Abstract A clonal derivative named P19CL6 has been isolated from pluripotent P19 mouse embryonic carcinoma cells, and this subline efficiently differentiates into beating cardiomyocytes when treated with 1% dimethyl sulfoxide (DMSO). It offers a valuable model to study cardiomyocytes differentia