Acyloxymethyl as a drug protecting group
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Teresa Calheiros; Jim Iley; Francisca Lopes; Rui Moreira
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Article
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1995
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Elsevier Science
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English
โ 213 KB
Tertiary N-acyloxymethylsulfonamide prodrugs 3, encompassing penicillin and sulfonamide antibiotics, have been synthesised. The pH-independent hydrolysis of these compounds ocurrs via the rate-determining formation of an N-sulfonyl iminium ion. SCF-MO calculations using the PM3 method indicate that