Acute West Nile virus neuroinvasive infections: Cross-reactivity with dengue virus and tick-borne encephalitis virus

✍ Scribed by Anna Papa; Dimitra Karabaxoglou; Athina Kansouzidou

• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 67 KB
• Volume: 83
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.22180

✦ Synopsis

Abstract

Cross‐reactions in serology are common among flaviviruses. During the outbreak of West Nile virus (WNV) infections in Greece in 2010, WNV IgM‐positive serum and cerebrospinal fluid samples were tested for the presence of IgM and IgG antibodies against Dengue virus (DENV) and tick‐borne encephalitis virus. Higher cross‐reactivity was observed in IgM antibodies between WNV and DENV; however, the index of the WNV antibodies was in all cases higher than that of the DENV antibodies. There is a need for caution when evaluating serologic results of flaviviral infections, while efforts have to be focused on the development of diagnostic assays with increased specificity. J. Med. Virol. 83:1861–1865, 2011. © 2011 Wiley‐Liss, Inc.