Acute toxicity of all-trans-retinoic acid loaded poly(L-lactide)/poly(ethylene glycol)-poly(L-lactide) microspheres in mice

Indomethacin-loaded methoxy poly(ethylen

Indomethacin-loaded methoxy poly(ethylene glycol)/poly(D,L-lactide) amphiphilic diblock copolymeric nanospheres: Pharmacokinetic and toxicity studies in rodents

✍ So Yeon Kim; Young Moo Lee; Ju Seop Kang 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 446 KB

## Abstract Biodegradable methoxy poly(ethylene glycol)/poly(D,L‐lactide) amphiphilic block copolymeric nanospheres were prepared for application as a particulate drug carrier. Drug‐loaded nanospheres (ML50) showed a narrow size distribution with the average diameter of <200 nm. When the feed weigh