✦ LIBER ✦

Acute theophylline toxicity and the use of esmolol to reverse cardiovascular instability

✍ Scribed by Michael Seneff; James Scott; Bruce Friedman; Mark Smith

Publisher: Elsevier Science
Year: 1990
Tongue: English
Weight: 310 KB
Volume: 19
Category: Article
ISSN: 1097-6760
DOI: 10.1016/s0196-0644(05)82474-6

No coin nor oath required. For personal study only.

✦ Synopsis

Theophylline overdoses are frequent conditions that may require emergency treatment. Clinical features common to severe theophylline toxicity include nausea and vomiting, tachydysrhythmias, metabolic disturbances, seizures, and cardiovascular collapse. Several reports have described these manifestations and their treatments. We report the case of a patient suffering from an acute, intentional theophylline overdose who exhibited the classic features of a toxic ingestion and describe the first reported use of IV esmolol in the treatment of accompanying cardiovascular manifestations.

📜 SIMILAR VOLUMES

Use of the Up-and-Down Acute Toxicity Te

Use of the Up-and-Down Acute Toxicity Test Procedure to Generate LC50 Data for Fish

✍ R. M. Sunderam; R. W. Patra; M. Julli; M. St. J. Warne 📂 Article 📅 2004 🏛 Springer 🌐 English ⚖ 854 KB

Use of various acute, sublethal and earl

Use of various acute, sublethal and early life-stage tests to evaluate the toxicity of refinery effluents

✍ James Sherry; Brian Scott; Bernard Dutka 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 84 KB 👁 1 views

The toxicities of effluents from three Ontario, Canada, refineries were assessed with microbes, plants, invertebrates, and fish. Acute toxicity was assessed by the Microtox test, an assay based on electron transport activity in submitochondrial particles, and Daphnia magna (water flea) and Oncorhync

Acute Toxicity of Nitrite and Ammonia to

Acute Toxicity of Nitrite and Ammonia toDaphnia similoidesof Different Developmental Stages: Using the Modified Gaussian Model to Describe

✍ Fuhui Xiang; Wei Yang; Yafen Chen; Zhou Yang 📂 Article 📅 2010 🏛 Springer 🌐 English ⚖ 214 KB

A new approach to minimizing the number

A new approach to minimizing the number of animals used in acute toxicity testing and optimizing the information of test results

✍ E. Schütz; H. Fuchs 📂 Article 📅 1982 🏛 Springer-Verlag 🌐 English ⚖ 788 KB

170 acute toxicity determinations, carried out in rats, mice, and guinea pigs after oral and parenteral administration during the past 5 years, using 5 c~/5 9 animals per dose, were evaluated with respect to the possibility of a reduction of animals necessary for obtaining LDs0 values with limits of

Acute and Chronic Toxicity of Veratrum V

Acute and Chronic Toxicity of Veratrum Viride††The Veratrum viride studied was the whole-powdered drug marketed by Irwin, Neisler & Co. under the name, Vertavis. The work reported herein was supported by a grant from this firm. The batch of powder used in these experiments was stated by the manufacturer to have been assayed biologically by the Craw method on Daphnia magna. One Craw unit of the material studied was stated to be 15.6mg. With regard to this assay, Mr. R. O. Craw has been so kind as to allow us to publish a brief explanation: A reference lot of Yerolrum oirid; powder was set-aside as a standard and a 10% w/v aqueous extract was made of this powder. The average median length of life in 50 assays of 1000 daphnia on immersion in the solution was determined to be 2.22 hours. The daphnia were considered dead when the heart was found to be in systolic standstill on microscopic examination. Succeeding lots of powder were assayed and their potency determined by relating the median length of life of daphnia to 2.22 hours, which is one unit. Twenty assays of 10 animals each were used on each lot of powder.‡‡The authors wish to thank Dr. J. F. A.,McManus of the Department of Pathology for a pathologic report on the tissues, and Mr. James Thomas and Mrs. Bobby E. Teague for technical assistance.

✍ Perdue, Adoline S. ;Bell, Frances ;Starnes, W.R. ;Hitchcock, Philip ;Teague, R.S 📂 Article 📅 1950 🏛 Elsevier ⚖ 346 KB 👁 1 views