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Acute stent thrombosis after early withdrawal of platelet glycoprotein IIb/IIIa antagonists: Potential rebound prothrombotic effect?

✍ Scribed by Dominick Joseph Angiolillo; Manel Sabaté; Antonio Fernández-Ortiz; Carlos Macaya


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
193 KB
Volume
58
Category
Article
ISSN
1522-1946

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✦ Synopsis


Abstract

We report on two cases of acute coronary stent thrombosis after early withdrawal of different competitive inhibitors of the platelet glycoprotein IIb/IIIa receptor, eptifibatide and tirofiban. Differences in pharmacokinetics between different types of glycoprotein IIb/IIIa receptor blockers and a potential rebound prothrombotic effect with the use of these antiplatelet drugs are reviewed. Cathet Cardiovasc Intervent 2003;58:481–484. © 2003 Wiley‐Liss, Inc.