Acute renal and hepatic effects induced by 3-haloanilines in the fischer 344 rat

✍ Scribed by Gary O. Rankin; Monica A. Valentovic; Derek W. Nicoll; J. G. Ball; Dianne K. Anestis; Patrick I. Brown; John L. Hubbard

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 720 KB
• Volume: 15
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/jat.2550150214

✦ Synopsis

Haloanilines are commonly used as chemical intermediates in the manufacture of a wide range of products. The purpose of this study was to examine the in vivo nephrotoxic and hepatotoxic potentials of the 3haloanilines. The in vitro effects of the 3-haloanilines on renal function were also examined. In the in vivo experiments, male Fischer 344 rats (four rats/group) were administered a single intraperitoneal (i.p.) injection of an aniline hydrochloride (1.0 or 1.25 mmol kg-I) or vehicle. Renal and hepatic function were monitored at 24 andor 48 h post-treatment. None of the 3-haloanilines were potent nephrotoxicants at either dose level. The greatest effects on renal function were observed following administration of 3-chloroaniline at a dose of 1.25 mmol kg -I (oliguria, glucosuria, hematuria, decreased paminohippurate accumulation by renal cortical slices and increased blood urea nitrogen concentration). 3-Chloroaniline also was the only aniline compound to increase plasma ALTIGPT activity at 48 h. In the in vitroexperiments, the ability of an aniline (lo-'-10-3M) to decrease organic ion accumulation in renal cortical slices from untreated rats was examined. The decreasing order of in vitro nephrotoxic potential was 3-iodoaniline > 3-bromoaniline > 3-chloroaniline > aniline > 3fluoroaniline. These results indicate that the 3-haloanilines are not potent nephrotoxicants or hepatotoxicants at sublethal doses. In addition, the reasons why the 3-haloanilines have different orders of nephrotoxic potential in vivo and in vitro are not clear at this time.