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Acute regulation of steady-state GABA levels following GABA-transaminase inhibition in rat cerebral cortex

✍ Scribed by Robin A. de Graaf; Anant B. Patel; Douglas L. Rothman; Kevin L. Behar


Book ID
116764792
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
269 KB
Volume
48
Category
Article
ISSN
0197-0186

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## Abstract Vigabatrin and gabaculine, both highly specific inhibitors of GABA (γ‐aminobutyric acid) transaminase, cause significant elevation of endogenous GABA levels in brain. The time course of GABA concentration after acute GABA transaminase inhibition was measured quantitatively in the α‐chlo