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Acute reduction of brain substance P induced by nicotine

โœ Scribed by N. E. Naftchi; H. Maker; E. Lapin; J. Sleis; A. Lajtha; S. Leeman

Book ID
105021374
Publisher
Springer
Year
1988
Tongue
English
Weight
508 KB
Volume
13
Category
Article
ISSN
0364-3190

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We investigated the effects of a schizophrenomimetic drug, phencyclidine (PCP), on substance P (SP) contents in the discrete rat brain areas using an enzyme-immunoassay for SP. The acute intraperitoneal (i.p.) administration of PCP (10 mg/kg), which is a noncompetitive antagonist of the N-methyl-D-a