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Acute recurrent polyhydramnios and amniotic prolactin

✍ Scribed by Marco De Santis; Anna Franca Cavaliere; Giuseppe Noia; Lucia Masini; Edoardo Menini; Alessandro Caruso


Book ID
101236633
Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
40 KB
Volume
20
Category
Article
ISSN
0197-3851

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✦ Synopsis


A 25 year-old patient in her third pregnancy presented with acute polyhydramnios at 24 weeks' gestation, which was the same time as in the two previous pregnancies. In both she had preterm premature rupture of membranes, preterm delivery and neonatal deaths. In the third pregnancy, amnioreductions combined with medical treatment resulted in the birth by Caesarean section of a normally formed live male at 31 weeks of pregnancy. Acute recurrent polyhydramnios is an extremely rare condition of unknown aetiology. We hypothesized that amniotic prolactin plays a role in this pathology. It was measured serially in amniotic ¯uid and high levels were found.


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A case of acute polyhydramnios in a fetus with pseudohypoaldosteronism is presented. Although rare, metabolic causes for polyhydramnios should be considered when no obvious cause is found in workup of the pregnant woman and when structural survey of the fetus is normal.