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Acute preclinical toxicity study of Zanthoxylum naranjillo extract

✍ Scribed by Élcio R. Rodrigues; Antenor H. P. Pedrazzi; Jairo K. Bastos

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
95 KB
Volume
12
Category
Article
ISSN
0951-418X

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✦ Synopsis

In previous studies, Zanthoxylum naranjillo hexane crude extract revealed marked analgesic and antimalarial activities. This paper reports an investigation of preclinical toxicity in acute phase ( 24 h and 15 days with repeated doses ) in which the action of different extract doses ( 15, 150 and 450 mg/kg ) was evaluated. Wistar rats weighing 300 AE 15 g were submitted to toxicological evaluation of clinical chemical, haematological and haemostatic blood parameters including evaluation of liver, pancreas, kidneys, bile ducts, heart, serum lipids, bonc marrow, haematological and haemostatic systems. The initial results showed an alteration of albumin and alkaline phosphatase at some of the doses tested, but without suggesting hepatic or biliary involvement.

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