Acute occlusive ischemia of the rat intestine: Early detection by MR imaging with polylysinemgd-dtpa enhancement

✍ Scribed by Bernard E. Van Beers; Isabelle Mottet; Monique Delos; Jean-Franpis Goudemant; Roger Demeure; Jacques Pringot

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 569 KB
• Volume: 5
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.1880050505

✦ Synopsis

Abstract

The purpose of this study was to assess the potential role of MR h@ng with polylysine‐Gd‐DTPA enhancement in the early detection of acute occlusive inteetinal ischemia in a rat model. After deveecularhtion Of the distal ileum in 12 rats. T2‐Weighted fart spinecho MR images were acquired, followed by T1‐ weighted imagea before and after IV administration of 0.1 mmol/kg polylysine‐Gd‐DTPA. The signal intensity of the ischemic intestine did not differ signiflcantly from that of the normal intestine before the admlnistration of the contrast material. No mucoeal or submucosal edema or hemorrhage was found in the ischemic intestine at histologic examination. After the administration of polylysine‐Gd‐DTPA, the ischemic intestine lacked enhancement and its signal intensity was significantly lower than that of the normal inteatine. MR imaging with polylysine‐Gd‐DTPA enhancement can detect acute occlusive ischemia of the rat intestine at an carly stage.