HLAβB27 up-regulation causes accumulatio
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Matthew J. Turner; Monica L. DeLay; Shuzhen Bai; Erin Klenk; Robert A. Colbert
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Article
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2006
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John Wiley and Sons
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English
β 213 KB
π 1 views
Objective. HLA-B27 is implicated in the pathogenesis of spondylarthritis (SpA), yet the molecular mechanisms are incompletely defined. HLA-B27 misfolding has been associated with endoplasmic reticulum stress and activation of the unfolded protein response (UPR) in macrophages from HLA-B27/human β€ 2