Acute myeloid leukemia and transcription factors: role of erythroid Krüppel-like factor (EKLF)
✍ Scribed by Rosa Ayala, Joaquin Martínez-López, Florinda Gilsanz
- Book ID
- 119900724
- Publisher
- BioMed Central
- Year
- 2012
- Tongue
- English
- Weight
- 414 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1475-2867
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## Abstract The Sp/KLF family contains at least twenty identified members which include Sp1‐4 and numerous krüppel‐like factors. Members of the family bind with varying affinities to sequences designated as ‘Sp1 sites’ (e.g., GC‐boxes, CACCC‐boxes, and basic transcription elements). Family members
An essential role for the Kru ¨ppel-like transcription factor family has been determined in the regulation of remarkable processes including cell proliferation, differentiation, signal transduction, oncogenesis, and cell death. A member of this group, Kru ¨ppel-like factor 6 (KLF6), identified on th