Acute myelogenous leukemia (AML) and diabetes insipidus (DI): Further association with monosomy 7

✍ Scribed by S. E. Slater; P. K. Maccallum; F. Birjandi; B. Gibbons; T. A. Lister

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 194 KB
• Volume: 10
• Category: Article
• ISSN: 0278-0232
• DOI: 10.1002/hon.2900100313

✦ Synopsis

Diabetes insipidus (DI) is a rare complication of acute myelogenous leukemia (AML). Five of the six such cases described in the literature who had banded chromosomal studies performed had monosomy 7 and the sixth patient had de1(7)(q22). A further case of AML complicated by DI in whom banded chromosomal studies revealed a complex karyotypic abnormality, including monosomy 7, is reported.

The association between monosomy 7 and DI in AML appears specific but the reason for this association remains unclear.