Acute Myelogenous Leukemia

✍ Scribed by Farhad Ravandi, Francis Giles (auth.), Judith E. Karp MD (eds.)

• Publisher: Humana Press
• Year: 2007
• Tongue: English
• Leaves: 432
• Series: Contemporary Hematology
• Edition: 1
• Category: Library

✦ Synopsis

Acute Myelogenous Leukemia is a timely compilation of new concepts in the molecular pathogenesis and molecular therapy of acute myelogenous leukemia (AML). The focus is on selected critical molecular determinants of AML pathogenesis and pathophysiology and the exploitation of these factors by diverse therapeutic agents and modalities. Bringing together new concepts and findings in the basic and clinical science of AML, the book emphasizes the molecular basis for new therapies that stand to have the greatest potential impact on the clinical face of these diseases. The text provides insights into selected novel strategies currently and prospectively being developed, including interruption of specific signal transduction pathways, modulation of gene expression, attempts to reinstate differentiation, and immunomodulation. There is an emphasis throughout on the bidirectional flow of knowledge between the clinical and laboratory arenas, and both basic and clinical scientists will benefit from this translational text.

✦ Table of Contents

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Approaching the Treatment of AML from a Biological Perspective....Pages 3-23
Front Matter....Pages 25-25
Aberrant Transcription Factors in AML....Pages 27-42
Myelodysplasia-Related AML....Pages 43-70
Therapy-related AML....Pages 71-95
The DNA Damage Response, DNA Repair, and AML....Pages 97-131
Altered Apoptosis in AML....Pages 133-161
Drug Resistance Transporters in AML....Pages 163-173
Front Matter....Pages 175-175
Impact of Cytogenetics on Clinical Outcome in AML....Pages 177-192
APL: A Classic Tale of Bench to Bedside....Pages 193-228
Front Matter....Pages 229-229
Emerging Therapeutics for AML....Pages 231-246
FLT3: A Prototype Receptor Tyrosine Kinase Target in AML....Pages 247-261
Farnesyl Transferase Inhibitors in the Therapy of AML....Pages 263-274
Modulating Gene Expression as a Therapeutic Approach in the Treatment of AML....Pages 275-291
Differentiation Therapy in AML....Pages 293-312
Stem Cell Transplantation for AML....Pages 313-327
Tumor Vaccines in Leukemia....Pages 329-341
Front Matter....Pages 343-343
Treatment, Outcomes, and Challenges of Newly Diagnosed AML in Children and Adolescents....Pages 345-372
AML in Older Adults....Pages 373-384
Dameshek Smiles: Molecular Clues to the Chronic Myeloproliferative Disorders Unmasked....Pages 385-398
New Designs for Clinical Trials....Pages 399-415
Back Matter....Pages 417-426

✦ Subjects

Hematology; Oncology; Cancer Research; Internal Medicine