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Acute lymphocytic leukemia (all) in elderly patients

✍ Scribed by J. F. Virgilio; L. C. Moscinski; O. F. Ballester; C. Corrado; C. Guida; L. Balducci; H. Saba

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
354 KB
Volume
11
Category
Article
ISSN
0278-0232

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✦ Synopsis

Objective: To compare the clinical and biologic characteristics, response to therapy and outcome of adult patients with ALL above and below the age of 55.

Design: Retrospective review of clinical and laboratory data.

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## Abstract ## BACKGROUND Aberrant methylation of promoter‐associated cystosine‐guanine (CpG) islands is an epigenetic modification of DNA frequently observed in adult patients with acute lymphocytic leukemia (ALL). This epigenetic modification has been associated with gene silencing, malignant tr