Acute lymphoblastic leukemia in a patient with type 1 Gaucher disease developing 1 year after discontinuation of enzyme replacement therapy
✍ Scribed by Aditi Ranade; Sorin Selegean; Gagangeet Sandhu; Violette Ghali; Vijay P. Shah
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 215 KB
- Volume
- 85
- Category
- Article
- ISSN
- 0361-8609
No coin nor oath required. For personal study only.
✦ Synopsis
Higher rates of venous thromboembolism for Black-Americans are likely due to lower serum
25-hydroxyvitamin D levels
To the editor: The recent paper on disparities of thromboembolism in the United States concluded that heritability may be important in the etiology of venous thromboembolism among Black-Americans [1]. That is correct but not in the manner considered by the authors. As Black-Americans have darker skin than White-Americans, they have lower serum 25-hydoxyvitamin D [25(OH)D] levels, with mean value of 16 ng/mL compared with 26 ng/mL for White-Americans [2]. Lower serum 25(OH)D levels are a risk factor for cardiovascular disease in general [3] and venous thrombotic events in particular [4], as well as Type 2 diabetes mellitus [3]. A recent review concluded that the disparities in serum 25(OH)D levels can account for most of the 25% higher mortality rates for Black-Americans compared with White-Americans [5]. If Black-Americans were to supplement with 2,000-5,000 IU/day of vitamin D3, which would raise serum 25(OH)D levels from a mean value of 16 ng/mL to 30-50 ng/mL, they would significantly reduce their risk of venous thromboembolism, other cardiovascular diseases, Type 2 diabetes mellitus, many types of cancer, and a number of bacterial and infectious diseases [3,5].