Acute iritis associated with primary sjögren's syndrome and high-titer anti—SS-A/Ro and anti—SS-B/La antibodies. Treatment with combination immunosuppressive therapy
✍ Scribed by Alan J. Bridges; Robert P. Burns
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 332 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
Objective. We describe a patient with primary Sjogren's syndrome who developed severe, acute, anterior uveitis (iritis), an uncommon complication in this setting .
Methods. We present the case report of the clinical findings, course, treatment, and resolution of the acute uveitis. Titers of antiSS-A/Ro and anti-SS-BLa antibodies were assessed (by immunodiffusion), as were fluorescent antinuclear antibodies (on HEp-2 cells) and cryoglobulins.
Results. Initial treatment with topical steroids, oral prednisone (20 mg/day), and oral methotrexate was unsuccessful. The iritis resolved after combined treatment with intravenous cyclophosphamide (1,5OO mg/ month), high-dose prednisone (60 mg/day), and cyclosporine (5 mg/kg/day).
Conclusion. An uncommon, severe complication of primary Sjogren's syndrome is acute uveitis. Combination immunosuppressive therapy may be needed to control this condition.
Sjogren's syndrome is an autoimmune disorder characterized by autoantibodies, lymphocytic infiltra-From the