✦ LIBER ✦

Acute inhalation toxicity of 3,3-dimethyl-2-butanol in sprague-dawley rats

✍ Scribed by John T. James; Bernardita P. Infiesto; Michael R. Landauer

Publisher: John Wiley and Sons
Year: 1987
Tongue: English
Weight: 542 KB
Volume: 7
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550070504

No coin nor oath required. For personal study only.

✦ Synopsis

Sprague-Dawley rats were given 15, 70 and 140 min exposures to 15 mg/l 3,3-dimethyl-2-butanol, pinacolyl alcohol (PA), or 6-hour exposures to 0.2, 1.0 and 5.0 mg/l PA (1 mg/l = 240 ppm). A 50% mortality rate was obtained at the longest exposure to 15 mg/l. Sex related differences in the blood levels of PA and pinacolone were noted, and the surviving male rats failed to gain weight normally in the first week after exposure. In rats exposed to 5.0 mg/l for 6 hours, there were reductions in horizontal and vertical activity and the minute volume was 55% of controls at the end of exposure. Like many secondary alcohols, PA poses only a possible inhalation hazard; however, male rats may be somewhat more susceptible than females.

📜 SIMILAR VOLUMES

A 13-week vapor inhalation study of 3,3-

A 13-week vapor inhalation study of 3,3-dimethyl-2-butanol in sprague-dawley rats

✍ John T. James; Robert D. Armstrong; Glenn Leach; Richard L. Farrand; David Burne 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 682 KB

Four groups of male and female Sprague-Dawley rats were exposed for 13 weeks to 3,3-dimethyl-2-butanol (PA) at concentrations of 0.00, 0.20, 1.00 or 5.00 mg/l (1 mg/l = 240 ppm). Exposures were for 6 hr per day, 5 days per week with sacrifices at 7 and 13 weeks of exposure, and at 4 weeks after expo

Metabolism and Distribution of [2,3-14C]

Metabolism and Distribution of [2,3-14C]Acrolein in Sprague-Dawley Rats

✍ Richard A. Parent; Halina E. Caravello; Dale E. Sharp 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 820 KB

The metabolism and disposition of [2,3-'4C]acrolein was studied in Sprague-Dawley rats after oral or intravenous dosing. Four groups of ten rats (five male and five female) were dosed with radiolabeled acrolein intravenously at 2.5 mg kg-' (Group 2), orally by gavage at 2.5 mg kg-I, either as a sing

Developmental toxicity study with 3-(met

Developmental toxicity study with 3-(methylthio)propionaldehyde vapor by whole-body exposure of Sprague-Dawley rats

✍ Bryan Ballantyne; Raymond E. Schroeder 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 73 KB

Time-mated Sprague-Dawley rats were exposed whole body to analytically measured 3-(methylthio) propionaldehyde (3-MTP) vapor concentrations of 0 (air controls), 9.87, 58.3 and 127.8 ppm over gestational days (gd) 6-15 for 6 h day(-1). There was an exposure concentration-related maternal toxicity (cl

Comparison of chronic toxicity and carci

Comparison of chronic toxicity and carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in 2-year bioassays in female Sprague-Dawley rats

✍ Nigel J. Walker; Michael E. Wyde; Lawrence J. Fischer; Abraham Nyska; John R. Bu 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 544 KB

## Abstract The cancer bioassay for 2,3,7,8‐tetrachlorodibenzo‐__p__‐dioxin (TCDD) conducted by the Dow Chemical company in the mid 70s has been used extensively for conducting quantitative cancer risk assessments for human exposure to TCDD. More recently the National Toxicology Program (NTP) condu

Subchronic inhalation toxicity of 3.5-μm

Subchronic inhalation toxicity of 3.5-μm diameter carbon fibers in rats

✍ R. S. Waritz; B. Ballantyne; J. J. Clary 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB 👁 1 views

No effects were seen when rats were exposed for 6 h day ؊1 , 5 days per week, for 16 weeks to an atmosphere of 20 mg m ؊3 of carbon fibers (25 × 10 6 fibers m ؊3 ) and small amounts of fiber particulate resulting from preparation of the ultimate test material. The carbon fibers were made from polyac

Subchronic toxicity of PCB 105 (2,3,3′,4

Subchronic toxicity of PCB 105 (2,3,3′,4,4′-pentachlorobiphenyl) in rats

✍ I. Chu; R. Poon; A. Yagminas; P. Lecavalier; H. Håkansson; V. E. Valli; S. W. Ke 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 81 KB 👁 1 views

2,3,3Ј,4,4Ј-pentachlorobiphenyl; PCB 105; subchronic toxicity; rat The toxicity of 2,3,3Ј,4,4Ј-pentachlorobiphenyl (PCB 105) was investigated in Sprague-Dawley rats following dietary exposure to this substance at levels of 0, 0.05, 0.5, 5 or 50 ppm for 13 weeks. Growth rate and food consumption wer