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Acute hypoxia alters eicosanoid production of perfused pulmonary artery endothelial cells in culture

โœ Scribed by L.D. Martin; S.D. Barnes; R.C. Wetzel

Book ID
119051348
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
706 KB
Volume
43
Category
Article
ISSN
0090-6980

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Exposure to hypoxia (0% O2) for 4-24 h resulted in increased intracellular L-arginine content and increased activity of calpain, a calcium-dependent neutral cysteine protease, in pulmonary artery endothelial cells. Calpain-inhibitor I abolished the increased L-arginine content in hypoxic cells. When