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Acute Hyperhomocysteinemia Induces Microvascular and Macrovascular Endothelial Dysfunction

✍ Scribed by Thomas N. Abahji; Lars Nill; Nagatoshi Ide; Christiane Keller; Ulrich Hoffmann; Norbert Weiss


Book ID
113467079
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
255 KB
Volume
38
Category
Article
ISSN
0188-4409

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## Abstract An elevated level of homocysteine (Hcy) limits the growth and induces apoptosis. However, the mechanism of Hcy‐induced programmed cell death in endothelial cells is largely unknown. We hypothesize that Hcy induces intracellular reactive oxygen species (ROS) production that leads to the