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Acute Hepatotoxicity after High-Dose Methotrexate Administration to Rats

✍ Scribed by Bremnes, R. M. ;Smeland, E. ;Huseby, N.-E. ;Eide, T. J. ;Aarbakke, J.

Book ID
114801668
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
813 KB
Volume
69
Category
Article
ISSN
0901-9928

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## Abstract The pharmacokinetics and tissue distribution of methotrexate (MTX) were investigated after intravenous (i.v.) injection of free MTX (treatment I), MTX‐loaded proliposomes (treatment II), and empty proliposomes mixed manually with free MTX (treatment III), 8 mg kg^βˆ’1^, to rats using an H