✦ LIBER ✦

Acute hepatitis B viral infection in a patient with anti-HBs

✍ Scribed by Yuan-Jen Wang; Dr. Shou-Dong Lee; Jaw-Ching Wu; Kwang-Juei Lo

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 232 KB
Volume: 35
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890350211

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We report a patient with antibody to hepatitis B surface antigen (anti‐HBs) but no antibodies to other hepatitis B virus components, who developed acute symptomatic type B hepatitis. The possible explanations for this unusual serological pattern are 1) the antibody‐positive status, which developed against only a subdeterminant of hepatitis B surface antigen (HBsAg), arose naturally or as the result of cross‐reaction with a variety of antigens; and 2) seroconversion to anti‐HBs occurred in response to surface antigen of a mutant strain of hepatitis B virus (HBV). This anti‐HBs positivity, in the absence of antibody to hepatitis B core antigen, does not provide natural immunization against HBV infection, and so is not protective. Individuals who are positive to anti‐HBs antibody alone which is not elicited by HBV vaccine, should be vaccinated against possible HBV infection.

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