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Acute hemarthrosis: A histological, biochemical, and biomechanical correlation of early effects on the anterior cruciate ligament in a rabbit model

✍ Scribed by Kenneth K. Ishizue; Roger M. Lyon; Prof. David Amiel; Savio L-Y. Woo

Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
725 KB
Volume
8
Category
Article
ISSN
0736-0266

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✦ Synopsis

Abstract

The early histological, biochemical, and biomechanical characteristics of the anterior cruciate ligament (ACL) were determined in a rabbit model of acute hemarthrosis. The ACLs of 19 rabbits were given seven consecutive daily knee injections of 2 ml of fresh autologous blood, and then compared to contralateral ACLs from control knees injected with 2 ml of lactated Ringer's solution daily for 7 days. The rabbits were then sacrificed. Synovial proliferation with iron deposition within synoviocytes was observed; however, the architecture of the ACL was maintained. Additionally, the total collagen content, collagenase activity, and biomechanical properties of the ACL were unaltered.

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