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Acute glucocorticoid effects on the multicomponent model of working memory

✍ Scribed by Leonardo José Vaz; Márcia Pradella-Hallinan; Orlando Francisco Amodeo Bueno; Sabine Pompéia

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
141 KB
Volume
26
Category
Article
ISSN
0885-6222

No coin nor oath required. For personal study only.

✦ Synopsis

Objective

In comparison with basal physiological levels, acute, high levels of cortisol affect learning and memory. Despite reports of cortisol‐induced episodic memory effects, no study has used a comprehensive battery of tests to evaluate glucocorticoid effects on the multicomponent model of working memory. Here, we report the results of a double‐blind, placebo‐controlled, between‐subjects study.

Methods

Twenty healthy young men were randomly assigned to either acute cortisol (30 mg hydrocortisone) or placebo administration. Participants were subjected to an extensive cognitive test battery that evaluated all systems of the multicomponent model of working memory, including various executive domains (shifting, updating, inhibition, planning and access to long‐term memory).

Results

Compared with placebo, hydrocortisone administration increased cortisol blood levels and impaired working memory in storage of multimodal information in the episodic buffer and maintenance/reverberation of information in the phonological loop. Hydrocortisone also decreased performance in planning and inhibition tasks, the latter having been explained by changes in storage of information in working memory.

Conclusions

Thus, hydrocortisone acutely impairs various components of working memory, including executive functioning. This effect must be considered when administering similar drugs, which are widely used for the treatment of many clinical disorders. Copyright © 2011 John Wiley & Sons, Ltd.

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