Acute exercise reduces hepatic glucose production through inhibition of the Foxo1/HNF-4α pathway in insulin resistant mice

Acute exercise reduces insulin resistanc

Acute exercise reduces insulin resistance-induced TRB3 expression and amelioration of the hepatic production of glucose in the liver of diabetic mice

✍ Athos F. Lima; Eduardo R. Ropelle; José R. Pauli; Dennys E. Cintra; Marisa J.S. 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 182 KB

## Abstract TRB3 (a mammalian homolog of __Drosophila__) is emerging as an important player in the regulation of insulin signaling. TRB3 can directly bind to Ser/Thr protein kinase Akt, the major downstream kinase of insulin signaling. Conversely, physical exercise has been linked to improved gluco