Mast cell disease associated with acute
β
Vinod A. Pullarkat; Sheeja T. Pullarkat; David C. Calverley; Russell K. Brynes
π
Article
π
2000
π
John Wiley and Sons
π
English
β 68 KB
π 1 views
Mast cell disease (MCD), a proliferation of mast cells (MC), is occasionally associated with hematologic malignancies. Neoplastic MC have activating c-kit mutations. c-kit is a receptor tyrosine kinase required for the development, proliferation, and survival of MC. Interaction of c-kit with its lig