𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Acute Effects of Steroids On Immune Complex Profile of Patients with Systemic Lupus Erythematosus

✍ Scribed by Robert E. Boyd; Daniel A. Birchmore; Donald L. Kaiser; Alice C. Young; John S. Davis IV

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
631 KB
Volume
26
Category
Article
ISSN
0004-3591

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✦ Synopsis

Abstract

Eleven patients with active systemic lupus erythematosus, previously untreated, were studied to 1) determine the acute effect of corticosteroids on circulating immune complex (CIC) levels and 2) correlate the initial CIC profile with the development of organ system involvement. Using serial measurements of CIC as detected by assays for cryoglobulins and binding to Clq, Raji cells, and rheumatoid factor, we found that levels of CIC change little during the first month of high dose daily steroid therapy, but they uniformly decrease to near normal by 6 to 12 months. High levels of CIC detected by Raji cell assay early in the course of systemic lupus erythematosus and before steroid therapy appear to be predictive of the development of chronic lupus nephritis (P < 0.005).

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