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Acute effects of MK801 on kainic acid-induced seizures in neonatal rats

✍ Scribed by Carl E Stafstrom; Pushpa Tandon; Ariyuki Hori; Zhao Liu; Mohamad A Mikati; Gregory L Holmes

Book ID
108460474
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
421 KB
Volume
26
Category
Article
ISSN
0920-1211

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## Abstract Kainic acid (KA)‐induced status epilepticus (SE) is a well‐characterized model of excitotoxic neuronal injury. Excitotoxicity results from activation of specific glutamate receptors, with resultant elevation of intracellular Ca^2+^. The CA1 and CA3 subregions of the hippocampus are espe