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Acute effects of insulin on surface insulin receptors in isolated hepatocytes. Evidence for a recycling pathway

✍ Scribed by Anne M. Bonser; Peter Garcia-Webb


Book ID
117056611
Publisher
Elsevier Science
Year
1984
Tongue
English
Weight
296 KB
Volume
119
Category
Article
ISSN
0006-291X

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We investigated the effect of phorbol 12-myristate 13-acetate (PMA), a protein kinase C (PKC) activator on insulin receptors and insulin action in freshly isolated and primary cultures of rat hepatocytes. PMA (1 x 10(-7) M) did not alter insulin receptor numbers or affinity either acutely or chronic