Acute effects of cicletanine in angina pectoris

✍ Scribed by D. L. Murdoch; E. Henderson; H. J. Dargie; G. T. McInnes

• Publisher: Springer
• Year: 1993
• Tongue: English
• Weight: 274 KB
• Volume: 44
• Category: Article
• ISSN: 0031-6970
• DOI: 10.1007/bf00315287

✦ Synopsis

The anti-anginal properties of single doses of a new anti-hypertensive drug, cicletanine, were investigated in a double-blind, randomised, balanced, crossover comparison with placebo in sixteen patients with chronic stable angina pectoris. All subjects underwent treadmill exercise 2 h after drug administration and 24 h ambulatory ECG monitoring with ST scanning. Although there were significantly fewer episodes of ST depression on ambulatory monitoring after cicletanine, total exercise duration and time to 1 mm ST depression were unchanged. This report provides little evidence of an acute anti-anginal effect of cicletanine but longer term studies may be indicated to further evaluate this drug's potential role in the management of angina pectoris.