Acute and relapsing experimental autoimmune encephalomyelitis in IL-4- and α/β T cell-deficient C57BL/6 mice
✍ Scribed by Ming-Lang Zhao; Robert B Fritz
- Book ID
- 117337735
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 158 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0165-5728
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## Abstract Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system (CNS). Like MS, the animal model experimental autoimmune encephalomyelitis (EAE) is characterized by CNS inflammation and demyelination and can follow a relapsing–remitting (RR) or chronic (CH)
Early studies of murine experimental autoimmune encephalomyelitis (EAE) induced with myelin basic protein (MBP) divide various mouse strains into either "susceptible" or "resistant" phenotypes. Resistance is defined as lack of encephalitogenic responses after active immunization or adoptive transfer