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Acute and chronic effects of (−)-amphetamine on seizure threshold and brain catecholamines in mice

✍ Scribed by William H. Riffee; Michael C. Gerald

Book ID
115773527
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
332 KB
Volume
26
Category
Article
ISSN
0006-2952

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The effects of chronic administration an
The effects of chronic administration and withdrawal of (+)-amphetamine on seizure threshold and endogenous catecholamine concentrations and their rates of biosynthesis in mice
✍ William H. Riffee; Michael C. Gerald 📂 Article 📅 1977 🏛 Springer 🌐 English ⚖ 535 KB

The i.v. pentylenetetrazol seizure threshold was increased by 2.5 mg/kg and decreased by 15 mg/kg of a single (+)-amphetamine dose. After 7 consecutive days of amphetamine administration, tolerance developed to the decrease but not to the increase in seizure threshold. At 12--48 h after the last dos