Acute and chronic cyclooxygenase blockage in portal-hypertensive rats: Influence in nitric oxide biosynthesis
β Scribed by M Fernandez; JC Garcia-Pagan; M Casadevall; MI Mourelle; JM Pique; J Bosch; J Rodes
- Book ID
- 119755383
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- English
- Weight
- 124 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0016-5085
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π SIMILAR VOLUMES
Systemic and especially splanchnic arterial vasodilation accompany chronic portal hypertension. Different soluble mediators causing this vasodilation have been proposed, the strongest evidence being for nitric oxide (NO). No data exist if structural vascular changes may partly account for this vasod
Portal hypertension is associated with splanchnic hyperemia and increased plasma levels of prostacyclin. Recently, nitric oxide was proposed as a mediator of this arterial vasodilatation. We hypothesized that portal hypertension alters the relative contribution of prostacyclin and nitric oxide to sp