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Acute ammonia treatment in vitro and in vivo inhibits the synthesis of a neuroprotectant kynurenic acid in rat cerebral cortical slices

✍ Scribed by Tomasz Saran; Wojciech Hilgier; Tomasz Kocki; Ewa M. Urbanska; Waldemar A. Turski; Jan Albrecht


Book ID
114003693
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
77 KB
Volume
787
Category
Article
ISSN
0006-8993

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Kynurenic acid synthesis in cerebral cor
✍ Tomasz Saran; Wojciech Hilgier; Ewa M. UrbaΕ„ska; Waldemar A. Turski; Jan Albrech πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 131 KB

## Abstract Increased ammonia is a major pathogenic factor in hepatic encephalopathy (HE), a neurologic syndrome associated with glutamatergic dysfunction. Previous studies have shown that in rat cerebral cortical slices or a glia‐derived cell line, acute treatment with ammonia in vitro and in vivo