Acutaxylines A and B, two novel triterpenes from Dysoxylum acutangulum

✍ Scribed by Intan Safinar Ismail; Yuta Nagakura; Yusuke Hirasawa; Takahiro Hosoya; Mohd Izwan Mohd Lazim; Nordin Hj Lajis; Hiroshi Morita

• Publisher: Elsevier Science
• Year: 2009
• Tongue: French
• Weight: 264 KB
• Volume: 50
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2009.05.110

✦ Synopsis

Two novel triterpenes, acutaxylines A (1) and B (2) consisting of a cyclopentenone side chain at C-17 and an oxepan-2-ol, were isolated from the leaves of Dysoxylum acutangulum. The relative stereochemistry of 1 and 2 was determined by NOESY correlations. Acutaxyline B showed moderate cytotoxicity against human blood premyelocytic leukemia cells.