Acupuncture in drug treatment: Exploring its role and impact on participant behavior in the drug court setting

Supersaturation–nucleation behavior of p

Supersaturation–nucleation behavior of poorly soluble drugs and its impact on the oral absorption of drugs in thermodynamically high-energy forms

✍ Shunsuke Ozaki; Takuma Minamisono; Taro Yamashita; Takashi Kato; Ikuo Kushida 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 257 KB

In order to better understand the oral absorption behavior of poorly water-soluble drugs, their supersaturation-nucleation behavior was characterized in fasted state simulated intestinal fluid. The induction time (t ind ) for nucleation was measured for four model drugs: itraconazole, erlotinib, tro