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Activity of recombinant trypsin isoforms on human proteinase-activated receptors (PAR): mesotrypsin cannot activate epithelial PAR-1, -2, but weakly activates brain PAR-1

✍ Scribed by Zoryana Grishina; Ewa Ostrowska; Walter Halangk; Miklós Sahin-Tóth; Georg Reiser

Book ID: 110008910
Publisher: Nature Publishing Group
Year: 2005
Tongue: English
Weight: 194 KB
Volume: 146
Category: Article
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706410

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## Abstract Proteinase‐activated receptor‐1 (PAR1), upon activation, exerts prostanoid‐dependent gastroprotection, and increases prostaglandin E~2~ (PGE~2~) release through cyclooxygenase‐2 (COX‐2) upregulation in rat gastric mucosal epithelial RGM1 cells. However, there is a big time lag between t